新聞中心
緊跟行業(yè)步伐，共享前沿資訊
industry
news
行業(yè)新聞
梅毒的病因和發(fā)病機理與TP抗原的關系
2018-08-24 15:34
說起梅毒，在古代這可是非?？膳碌囊环N病。而現(xiàn)代來說，人一旦得了梅毒，其實也是比較難以啟齒的。那么，梅毒的病因與發(fā)病機理到底是怎么樣的呢?我們一起來了解一下吧!
Speaking of syphilis, in ancient times, it was a very terrible disease. In modern times, once people get syphilis, it is also hard to say. Then, what is the cause and pathogenesis of syphilis? Let's get together to understand it.
TP通常不易著色，故又稱蒼白螺旋體，由8-14個整齊規(guī)則、固定不變螺旋結構形成，螺旋折光性強，長4-14μm，寬0.2μm，可以旋轉、蛇行、伸縮三種方式運動。TP人工培養(yǎng)困難，一般接種于家兔睪丸進行保存和傳代。TP體系厭氧微生物，脫離人體不易生存，煮沸、干燥、日光、肥皂水和普通消毒劑都可迅速將其殺滅。
TP is usually not easy to stain, so it is also known as the pale spirochete, formed by 8-14 regular, fixed and unchanged spiral structure, spiral refractive, 4-14 micron long, 0.2 micron wide, can rotate, snake, stretch three ways of movement. TP is difficult to culture and is commonly inoculated in rabbit testes for preservation and passage. Anaerobic microorganisms in the TP system, which are difficult to survive without human body, can be quickly killed by boiling, drying, sunlight, soap water and ordinary disinfectants.
TP表面的黏多糖酶與其致病性有關，TP對皮膚、主動脈、眼、胎盤、臍帶等富含粘多糖的組織有較高的親和力，可借其黏多糖酶吸附到上述組織細胞的表面，分解黏多糖造成組織血管塌陷，血供受阻，進而導致管腔閉塞性動脈內(nèi)膜炎、動脈周圍炎，出現(xiàn)壞死、潰瘍等病變。
The mucopolysaccharidase on the surface of TP is related to its pathogenicity. TP has high affinity for mucopolysaccharide-rich tissues such as skin, aorta, eye, placenta and umbilical cord. It can be adsorbed on the surface of the above tissues and cells by its mucopolysaccharidase, which breaks down mucopolysaccharide and causes vascular collapse and blockage of blood supply, leading to lumen occlusive arteries. Membrane inflammation, periarteritis, necrosis, ulcers and other lesions.
TP含有許多抗原物質(zhì)，多數(shù)為非特異性，如心磷脂，僅少數(shù)為特異性，如TP抗原。非特異性抗體，如心磷脂抗體。特異性抗體(即抗TP抗體)對機體無保護作用，在血清中可長期甚至終身存在。
TP contains many antigenic substances, most of which are nonspecific, such as cardiolipin, and only a few are specific, such as TP antigen. Nonspecific antibodies, such as cardiolipin antibodies. The specific antibody (anti TP antibody) has no protective effect on the body, and can exist in the serum for a long time or even for life.