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移動(dòng)測試方法使用了表面聲波(surface acoustic wave, SAW)生物芯片，該生物芯片基于在智能手機(jī)中發(fā)現(xiàn)的微型電子元件。這種一次性的石英生物芯片檢測非?？焖伲@是因?yàn)樗鼈儾⒉恍枰獜?fù)雜的標(biāo)記、放大或洗脫步驟，而且一種口袋大小的控制盒會(huì)讀出SAW信號(hào)，并通過電子方式顯示出結(jié)果。
The mobile test method uses the surface acoustic wave (SAW) biochip, which is based on the micro electronic components found in the smartphone. This one-off quartz biochip detection is very fast because they do not require complicated labeling, amplification or elution steps, and a pocket size control box reads the SAW signal and displays the results electronically.
較早地檢測HIV對(duì)協(xié)助控制潛在的疾病爆發(fā)是至關(guān)重要的，但是現(xiàn)有的測試方法需要復(fù)雜的分析儀器，而且為了獲得檢測結(jié)果需要等待較長的時(shí)間。
Early detection of HIV is essential to help control the outbreak of a potential disease, but the existing testing methods require complex analytical instruments and have to wait a long time to obtain the results of the test.
這些研究人員首先對(duì)SAW生物芯片和捕捉涂層進(jìn)行優(yōu)化，從而利用較小尺寸的駱駝抗體技術(shù)來檢測HIV抗體和重組抗原(分別是抗p24抗體和p24)。隨后，這種測試方法被用來檢測真實(shí)的病人樣品，以便在幾秒內(nèi)實(shí)現(xiàn)較高的特異性和靈敏度。
The researchers first optimized the SAW biochip and capture coating to detect HIV antibodies and recombinant antigens using smaller size camel antibody techniques (anti p24 antibodies and p24, respectively). Subsequently, this test method was used to detect real patient samples in order to achieve high specificity and sensitivity within a few seconds.
這項(xiàng)研究打開了利用消費(fèi)電子產(chǎn)品降低較長的測試等待時(shí)間的潛力，從而讓病人在現(xiàn)場獲得潛在的拯救生命的療法，并且支持更為及時(shí)的公共衛(wèi)生干預(yù)以便阻止疾病爆發(fā)。
The study opens the potential of using consumer electronics to reduce the longer test waiting time, allowing patients to get potential life-saving therapies on the spot and support more timely public health interventions to prevent the outbreak.
薩里大學(xué)轉(zhuǎn)化病毒學(xué)教授Vince Emery說：“這項(xiàng)研究表明我們能夠找到傳統(tǒng)醫(yī)學(xué)科學(xué)與前沿的移動(dòng)技術(shù)之間的很好的結(jié)合而使得在幾秒鐘內(nèi)診斷出嚴(yán)重的病毒感染，這產(chǎn)生了巨大的影響。”
Vince Emery, Professor of transformation of Virology at the University of Surrey, said: "this study shows that we can find a perfect combination of traditional medical science and the frontier of mobile technology that can make a serious virus infection in a few seconds, which has a huge impact."
“我們開發(fā)出這種利用現(xiàn)存的智能手機(jī)技術(shù)在10秒內(nèi)檢測出HIV的測試方法，但是它在理論上能夠用于檢測一系列疾病，比如寨卡病毒或埃博拉病毒，這潛在地意味著我們能夠在嚴(yán)重的疾病爆發(fā)變成大范圍的流行病之前，鑒定出它們，特別是如果我們在未來能夠?qū)⑦@種測試方法與正在發(fā)展中的5G技術(shù)相結(jié)合的話。”
"We have developed a test method that uses the existing smartphone technology to detect HIV in 10 seconds, but it can be used in theory to detect a series of diseases, such as the Zhai card virus or Ebola virus, which potentially means that we can identify it before a serious outbreak becomes a large epidemic. Especially if we can combine this testing method with the developing 5G technology in the future. "
較早的診斷和進(jìn)行抗逆轉(zhuǎn)病毒治療可將預(yù)期壽命提高10年，將嬰兒死亡率降低70%，而且孕婦幾乎完全能夠阻止將病毒感染傳播給她們的嬰兒。
Early diagnosis and antiretroviral treatment can increase life expectancy by 10 years, reduce infant mortality by 70%, and pregnant women are almost completely able to stop the transmission of the virus infection to their babies.
倫敦大學(xué)學(xué)院生物醫(yī)學(xué)納米技術(shù)教授Rachel McKendry說：“這是一個(gè)激動(dòng)人心的突破，為未來的臨床研究和產(chǎn)品開發(fā)奠定了基礎(chǔ)。”
"This is an exciting breakthrough that lays the foundation for future clinical research and product development," said Rachel McKendry, a professor of biomedical nanotechnology at the University College London.
“如果取得成功的話，這種平臺(tái)技術(shù)可能引發(fā)HIV快速診斷變革，并且給全世界數(shù)百萬人帶來重大的健康和經(jīng)濟(jì)效益。”
"If success is achieved, this platform technology can cause HIV rapid diagnostic changes and bring significant health and economic benefits to millions of people all over the world."
OJ-Bio公司首席執(zhí)行官Dale Athey博士解釋道：“當(dāng)前基于側(cè)向流動(dòng)技術(shù)的HIV即時(shí)檢測仍然相對(duì)較慢，大多需要10～20分鐘的時(shí)間獲得測試結(jié)果。在英國，這超過了醫(yī)生大約9分鐘的預(yù)約時(shí)間。”
Dr. Dale Athey, chief executive of OJ-Bio, explained: "the current HIV real-time detection based on lateral flow technology is still relatively slow, most of which takes 10~20 minutes to get the test results. In Britain, this exceeds the appointment time of doctors about 9 minutes.