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HIV感染的三種臨床類型Three clinical types of HIV infection
2017-02-04 11:00
(1)典型進(jìn)展者 Typical progress
在感染早期，其免疫功能未受損害，但在8～10年內(nèi)免疫能力逐漸下降，最后發(fā)展成為艾滋病。
In the early stage of infection, the immune function was not damaged, but in 8 to 10 years, the immune ability gradually declined, and finally developed into aids.
(2) 快速進(jìn)展者 Rapid progress
這個(gè)群體的CD4細(xì)胞計(jì)數(shù)在2～5年內(nèi)迅速下降，抗HIV的抗體水平很低，而且該抗體中和HIV的能力也較差，也可能有增強(qiáng)抗體。快速進(jìn)展者中非常顯著的特征是HIV感染后一直維持較高的病毒載量。
The CD4 cell count in this group decreased rapidly within 2 to 5 years, the level of antibody against HIV was very low, and the ability of the antibody to neutralize HIV was also poor. The most notable feature of rapid progression is a high viral load after HIV infection.
(3) 長(zhǎng)期存活者（又稱長(zhǎng)期不進(jìn)展者） long term survivors (also known as long-term non progressors)
這些感染者能維持健康狀態(tài)達(dá)12年以上，目前更長(zhǎng)已達(dá)17年，并且CD4細(xì)胞計(jì)數(shù)維持正常。此群體在所有感染者中的比例一般為8～10%，多為血友病患者、靜脈吸毒者、異性接觸者和新生兒。長(zhǎng)期存活者常常具有如下特征：病毒載量低（血漿和PBMC）、HIV毒株是相對(duì)非致病性毒株、針對(duì)個(gè)體中現(xiàn)存HIV毒株的抗體不會(huì)加重感染、PBMC產(chǎn)生Ⅰ型細(xì)胞因子、CD8細(xì)胞抗病毒反應(yīng)很強(qiáng)。
These infections can maintain health for more than 12 years, the longest has reached up to 17 years, and CD4 cell count remained normal. The proportion of this group in all infected persons is generally 8 to 10%, and most of them are hemophilia, intravenous drug users, heterosexual contacts and newborns. Long term survivors often have the following characteristics: low viral load (plasma and PBMC) and HIV were relatively non pathogenic strains and antibodies to individual HIV strains not existing aggravating infection, PBMC type cytokines and CD8 cell antiviral response is very strong.
在感染早期，其免疫功能未受損害，但在8～10年內(nèi)免疫能力逐漸下降，最后發(fā)展成為艾滋病。
In the early stage of infection, the immune function was not damaged, but in 8 to 10 years, the immune ability gradually declined, and finally developed into aids.
(2) 快速進(jìn)展者 Rapid progress
這個(gè)群體的CD4細(xì)胞計(jì)數(shù)在2～5年內(nèi)迅速下降，抗HIV的抗體水平很低，而且該抗體中和HIV的能力也較差，也可能有增強(qiáng)抗體。快速進(jìn)展者中非常顯著的特征是HIV感染后一直維持較高的病毒載量。
The CD4 cell count in this group decreased rapidly within 2 to 5 years, the level of antibody against HIV was very low, and the ability of the antibody to neutralize HIV was also poor. The most notable feature of rapid progression is a high viral load after HIV infection.
(3) 長(zhǎng)期存活者（又稱長(zhǎng)期不進(jìn)展者） long term survivors (also known as long-term non progressors)
這些感染者能維持健康狀態(tài)達(dá)12年以上，目前更長(zhǎng)已達(dá)17年，并且CD4細(xì)胞計(jì)數(shù)維持正常。此群體在所有感染者中的比例一般為8～10%，多為血友病患者、靜脈吸毒者、異性接觸者和新生兒。長(zhǎng)期存活者常常具有如下特征：病毒載量低（血漿和PBMC）、HIV毒株是相對(duì)非致病性毒株、針對(duì)個(gè)體中現(xiàn)存HIV毒株的抗體不會(huì)加重感染、PBMC產(chǎn)生Ⅰ型細(xì)胞因子、CD8細(xì)胞抗病毒反應(yīng)很強(qiáng)。
These infections can maintain health for more than 12 years, the longest has reached up to 17 years, and CD4 cell count remained normal. The proportion of this group in all infected persons is generally 8 to 10%, and most of them are hemophilia, intravenous drug users, heterosexual contacts and newborns. Long term survivors often have the following characteristics: low viral load (plasma and PBMC) and HIV were relatively non pathogenic strains and antibodies to individual HIV strains not existing aggravating infection, PBMC type cytokines and CD8 cell antiviral response is very strong.